vitamin B12 | vitamin B12 is a general term for vitamin B chemicals with a cobalt ring structure. There are four kinds of vitamin B12 family: cyanocobalamin, hydroxycobalamin, adenosylcobalamin and mecobalamin, which is a kind of vitamin B12. But vitamin B12 used clinically usually refers to cyanocobalamin. Cyanocobalamin (VB12) and hydroxycobalamin have no direct biological activity. Cyanocobalamin (VB12) is a prodrug and is converted into mecobalamin and adenosine cobalamin in vivo. Mecobalamin and cobalamin are two active coenzyme forms of vitamin B12 in vivo. Cyanocobalamin and hydroxycobalamin are dark red crystals or crystalline powders; cobalamin is yellow-orange hexagonal crystals, which turn dark red when exposed to air; mecobalamin is bright red needle-like crystals or crystalline powder. The four cobalamin injections are all red. In the usual storage of medicines, they need to be kept away from light. Cyanocobalamin is the most stable, and general light will not degrade it; cobalamin and mecobalamin are unstable when seeing light and must be strictly protected from light. When injected, the time must be shortened. All four cobalamin can prevent and treat erythrocyte anemia and peripheral neuropathy. In the human body, we can only directly use adenosylcobalamin and mecobalamin. Cyanocobalamin and hydroxycobalamin need to be converted into adenosylcobalamin and mecobalamin through the organelles in the liver to be used by the human body. If there are liver diseases, such as hepatitis and liver cirrhosis, adenosylcobalamin and mecobalamin should be directly supplemented to reduce the burden on the liver. Patients with liver function damage can be preferred. |